Eczema patients could get answers by scientists arms for the disorder- spurring Staphylococcus aureus by just picking out helpful although infrequent bacteria from their skin, growing it up to substantial quantities, and mixing it with off the shelf lotion that the patients slathered on. The finding, reported this week in Science Translational Medicine, is another case of using the protective and disease-fighting potential of the human microbiome. Researchers are optimistic that without the hazards that come with antibiotics, the bacteria boosts that are personal will prove useful in longterm treatment in future clinical trials.
“This strategy is fundamentally superior to current pharmaceutically ” the authors conclude. Unlike bottled antibiotics that could kill microbes indiscriminately—friends or foes—the patient’s skin bacteria selectively killed off dangerous S. aureus and left the protective community complete.
The researchers, headed by dermatologist Richard Gallo of the University of California, San Diego, developed the treatment approach by first noting that individuals with healthy skin possess a couple of normal skin bacteria that seemed to keep S. aureus in check. But on people who have atopic dermatitis (AD)—a kind of eczema that results in dry, itchy spots of skin—those helpful skin bacteria are much less plentiful.
And when those compounds mixed with antimicrobial compounds made by the human skin, the compounds functioned synergistically—that is, collectively they were more deadly to S. aureus than the sum of their independent killing abilities. Yet, they still left other benign and beneficial microbes unharmed.
Nevertheless, the researchers grew the forms in laboratory, creating vast amounts. Then they combined the microbe slurry having a moisturizer that was standard. The end result was five patient-special lotions brimming with helpful, personally derived microbes.
Then, the five patients slathered one of their arms with their probiotic lotion that was personalized with the other as well as plain lotion. The final concentration of microbes from the lotion that is slathered was around 100,000 colony-forming units per square centimeter of skin. This can be all about the same density of bacteria that you’d discover on healthy skin.
After 24 hours—with no bathing—S. aureus levels fell substantially on the arms of three patients with microbe-laden lotion. The germ that was harmful evaporated entirely on the treated limbs of the other two patients. You can access more details on it at skin pain forum.